DsDNA levels?

DsDNA levels?

I'm newly diagnosed in November, and my dsDNA levels keep climbing every time they test them, currently at 23, was at 16 on first test. Is this really high? What are other's levels? I read somewhere that increase of dsDNA of more than 25% can be indication of a flare, even before c3/c4 show, and greater risk of kidney issues, but i have no sense of how high my levels are compared to others with Lupus. Thanks.

A MyLupusTeam Member said:

When I was first diagnosed (a year ago today actually), my dsDNA was over 1,000. Naturally, my Rheumatologist was very concerned and put me on Plaquenil and a high dose of Prednisone immediately, which dropped it down into the 200s relatively quickly. I have since tapered off the Prednisone and started on Mycophenalate recently to see if it will help it lower some more since it plateaued around 60. Somehow, despite my high dsDNA, I have been clear of lupus nephritis so far, which was what my rheumatologist was worried about. I also see nephrology just to keep an eye on it. My Rheumatologist thinks that I have been living with lupus for much longer than I realize, which is how the dsDNA got so high. That is the tricky thing about lupus, it manifests so differently with all of us from a symptom and bloodwork standpoint! Best of luck to you and never hesitate to bring these questions up with your MD!

posted 4 months ago
A MyLupusTeam Member said:

Depends on the scale used and the way the lab tests for it , all scales are different , some scales have to be over 330 to be considered positive , I was 229 and they read it as negative when in fact I’m always positive so usually once your positive with dsdna you will always test positive for it just the number will change , another test I was highly positive at 40 , 23 doesn’t seem too high to me but if it’s using the test that says greater than 10 is positive than it is still positive although not a high positive , if it’s using the scale that says greater than 330 is positive than it’s not positive lol in other words it depends on the lab and how they run the test

edited, originally posted 4 months ago
A MyLupusTeam Member said:

Yes in time the plaquenil should reduce your numbers. I was on plaquenil and predisone plus I was on mycophenalate for lupus nephritis which affects the kidneys. Later on I was put on methoextrate.
I now only take plaquenil.

posted 4 months ago
A MyLupusTeam Member said:

I would say that lupus is active. When I was first diagnosed in 2014 my anti dsdna was 86. Right
now it’s a1.

posted 4 months ago
A MyLupusTeam Member said:

So far I'm on Plaquenil and aspirin for antiphospholipid syndrome. Does being on the plaquenil help lower the dsDNA? If that number keeps climbing, does it mean i need new meds? New to all this. Appreciate the responses!

posted 4 months ago
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