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Real members of MyLupusTeam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.

How Long Did It Take For Leflunomide To Start Working For You?

A MyLupusTeam Member asked a question 💭
Venice, FL

I started a week ago and I feel super exhausted. Not sure if that’s a side effect? No stomach issues though so that’s good. How long did it take to see a difference on the Leflunomide (Arava brand name) ?

October 5, 2020 (edited)
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A MyLupusTeam Member

Ive been on Arava for at least 12years now . It was an absolute turning point for me . Responded so favorably . Best 1 so far

October 8, 2020
A MyLupusTeam Member

I've been on leflunomide for almost 3 months. The first 2 months I could tell absolutely no difference and wanted to stop the medication, but my rheumatologist asked me to continue at least another month. About 2 weeks into the 3rd month I started telling a difference and I do believe it has helped the pain in my hands and ankle.

October 6, 2020
A MyLupusTeam Member

Thanks for responding! I’m trying to not get fustrated but I know I need to be patient.

October 6, 2020
A MyLupusTeam Member

They started me on steroids and Plaquenil. It took 3 months which was actually good because he said it could be up to 6 months. I am so sorry you are exhausted, I know the feeling and it is overwhelming. If you can take a nap, then do it. If you can't make dinner oh well. It is your time to get better and you will.

October 6, 2020
A MyLupusTeam Member

I was put on Leflunomide in 2019 when I got worse on the Plaquenil. My hair was falling out bad, achy legs, joint pain, and really bad diarrhea. It took about 2 months to start feeling better. I am currently still on Plaquenil 400mg daily and Leflunomide 20mg mg daily. Around March 2023 my symptoms began worsening again. Skin eruptions began along with all the previous symptoms. Had a biopsy of the spots on my back, that's when my Lupus diagnosis was confirmed. I'm now doing Saphnelo Infusions, which I began a little over a week ago. My skin problems are cleared up. So, yes Leflunomide does work it just takes a little time depending on how bad your symptoms.

February 24, 2024

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