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Leukopenia, defined as a white blood cell count of less than 4,000 cells per microliter, is common in people with lupus. This condition can contribute to extreme fatigue. In lupus, changes in blood cell counts are often linked with disease activity and can indicate additional health problems. Many people with lupus report Show Full Answer

Leukopenia, defined as a white blood cell count of less than 4,000 cells per microliter, is common in people with lupus. This condition can contribute to extreme fatigue. In lupus, changes in blood cell counts are often linked with disease activity and can indicate additional health problems. Many people with lupus report feeling fatigue, with studies showing between 67 percent and 90 percent experiencing it. If you're experiencing extreme fatigue, it's important to discuss this with your healthcare provider.

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