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Anyone have elevated TPO but normal thyroid bloodwork otherwise? I’ve had elevated TPO for probably 8 years that I am aware of. I wonder if

A MyLupusTeam Member asked a question 💭
NC

That is not causing some issues. Namely depression and anxiety, fatigue and neuropathy. How to get a doctor to take this seriously. Dr tells me the elevation means I am more at risk to develop thyroid issues. I read that the elevation means it’s already attacking the thyroid. My results have ranged from 170’s to low 100’s

February 13
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A MyLupusTeam Member

Frankie, this isn't something to worry about, and it's unlikely that it's causing your anxiety, since your thyroid function is normal. About one in twenty women in the US (most of whom don't have lupus or other autoimmune disease) have an underactive thyroid gland due to Hashimoto's, and it's very easily treated with a thyroid supplement. If you're really worried, you could consider seeing an endocrinologist to allay your fears, but regular follow-up of your thyroid function, as your doctor is doing, is the usual recommendation.

February 14
MyLupusTeam

Are elevated TPO antibodies with normal thyroid levels causing symptoms like depression, anxiety, fatigue, and neuropathy?

You're right to be concerned. Elevated TPO (anti-thyroid peroxidase) antibodies do indicate that your immune system is attacking your thyroid, even when other thyroid bloodwork appears normal. This is Show Full Answer

Are elevated TPO antibodies with normal thyroid levels causing symptoms like depression, anxiety, fatigue, and neuropathy?

You're right to be concerned. Elevated TPO (anti-thyroid peroxidase) antibodies do indicate that your immune system is attacking your thyroid, even when other thyroid bloodwork appears normal. This is particularly relevant for people with lupus, as thyroid conditions and lupus often overlap.

Thyroid antibodies commonly overlap with the antinuclear antibodies (ANA) seen in lupus. Hypothyroid conditions are more common in people with lupus than in the general population, and the symptoms you're experiencing—depression, anxiety, fatigue, and neuropathy—can be associated with both lupus and thyroid dysfunction.

Here's what might help when talking to your doctor:

* Request routine thyroid monitoring, including TSH and Free T4 tests, not just TPO levels
* Keep a symptom diary documenting how depression, anxiety, fatigue, and neuropathy affect your daily life
* Ask about the possibility of subclinical hypothyroidism (when TSH is slightly elevated but still in "normal" range)
* Consider requesting a referral to an endocrinologist who specializes in thyroid conditions

A MyLupusTeam member mentioned getting annual thyroid checkups, which shows the importance of regular monitoring when you have elevated antibodies. About feeling dismissed:

If you feel your doctor isn't taking your concerns seriously, know that this is unfortunately common. Research shows that when healthcare providers dismiss or downplay symptoms, it can lead to delayed care and increased anxiety and depression. Some people even avoid future medical visits after being dismissed.

You have the right to advocate for yourself. If your current doctor won't investigate further despite 8 years of elevated TPO and ongoing symptoms, consider seeking a second opinion or asking for that endocrinology referral directly.

February 13
A MyLupusTeam Member
February 15

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