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Real members of MyLupusTeam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.
A MyLupusTeam Member asked a question 💭
London, UK

Since 2019 I have been taking: Ursodexycolic Acid, Hydoxychloroquine, Predisone when ever i have a flare, vitamin D3, B12 and Magnesium
My kidneys are great, but two docs are not sure if the lupus is what caused the liver damage. and i don't drink alcohol. It's called Non-Alcohol Liver disease or Chronic Liver disease
I told my doc to find a substitute for prednisone, because i was putting on a lot of weight. So i started taking Rituximab. After two years of being on rituximab, while being… read more

July 12
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A MyLupusTeam Member

Thanks for your response. Very much appreciated. I also take before eating: Pantaprazole and Propranolol to coat my stomach from the strong medications. I also have a host of other internal issues, eg: enlarged spleen, bile duct damage, swollen stomach, ankles, diverticulosis, quite a few more but i cannot remember them because the docs don't really speak of them. but on the results you can see their findings. they only pay attention to the more critical issues. (i realize).I was asking about the liver because I don't really hear anyone speak of the liver with lupus, it's mostly the kidneys. Thanks for confirming.

July 12 (edited)
MyLupusTeam

Yes, lupus absolutely can affect the liver. Between 25% and 60% of people with lupus experience some liver involvement during their illness. So you are definitely not alone in this.

It's also worth knowing that some lupus medications themselves — including prednisone, NSAIDs, and methotrexate — can contribute to liver stress Show Full Answer

Yes, lupus absolutely can affect the liver. Between 25% and 60% of people with lupus experience some liver involvement during their illness. So you are definitely not alone in this.

It's also worth knowing that some lupus medications themselves — including prednisone, NSAIDs, and methotrexate — can contribute to liver stress and damage over time, which may be part of why your doctors are uncertain about the exact cause. What you're feeling about the transplant — the fear, the exhaustion, wanting to just let life take its course — that is completely understandable. Living with lupus and navigating this much medical complexity since 2019 is genuinely exhausting.

That said, it's really worth having an honest conversation with your doctor about those feelings before making any final decisions. Sometimes fear can quietly make decisions for us before we've had a chance to fully weigh things up.

A MyLupusTeam member once shared something that stuck: *"I cannot stress enough how important it is to listen to your body."* Your feelings matter as much as your test results.

You've clearly been fighting hard and advocating for yourself — asking for alternatives to prednisone, managing infusion reactions, relocating. That takes real strength. 💙

July 12

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