I had that before taking any medication, so could just be part of lupus
September 22
That's a really important symptom to pay attention to. Numbness in the fingers and toes isn't listed among the most commonly documented side effects of methotrexate, but that doesn't mean it isn't worth taking seriously.
The known common side effects of methotrexate include:
- Nausea, vomiting, and diarrhea
- Mouth sores or Show Full Answer
That's a really important symptom to pay attention to. Numbness in the fingers and toes isn't listed among the most commonly documented side effects of methotrexate, but that doesn't mean it isn't worth taking seriously.
The known common side effects of methotrexate include:
- Nausea, vomiting, and diarrhea
- Mouth sores or ulcers
- Fatigue and weakness
- Hair loss
- Headache
- Dizziness
- Decreased appetite
- Red eyes While numbness specifically isn't on that list, methotrexate does affect the nervous system in some people, and it's not something to brush off. It's really important to contact your doctor or rheumatologist as soon as possible to report this symptom.
It's also worth noting that side effects can be more pronounced at higher doses, and certain factors like age or kidney health can increase sensitivity to the medication.
Don't stop taking methotrexate without speaking to your doctor first — but do let them know what you're experiencing right away so they can evaluate whether a dose adjustment or alternative treatment might be needed.
September 22
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