Thankfully I do not have systemic as far as I know at this time. For a 2-3 years I was on Plaquenil until I discovered a potential dangerous drug interaction w/ my antidepressant (Zoloft) my rheumatologist didn’t seem too concerned but my doctor who prescribed me the Zoloft didn’t want to risk it so I switched to another. I tried a couple and nothing quite worked as well for me… so eventually decided to go back to Zoloft and go off the plaquenil hoping I could just manage the rashes topically… read more