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I have been taking plaquinel for 2 years now and no problem until now. Swollen painful feet and legs as well as easy bruising and petechial rash on ankles. Labs have all been ok

March 18, 2025
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MyLupusTeam

Yes, swelling in the legs and feet along with easy bruising can occur as lupus progresses. Swelling can be a sign of a lupus flare or could indicate lupus nephritis, which affects about 50% of people with lupus. While your labs are normal, it's still important to monitor these new symptoms closely. Given that these symptoms Show Full Answer

Yes, swelling in the legs and feet along with easy bruising can occur as lupus progresses. Swelling can be a sign of a lupus flare or could indicate lupus nephritis, which affects about 50% of people with lupus. While your labs are normal, it's still important to monitor these new symptoms closely. Given that these symptoms are new after 2 years on Plaquenil and include swelling, bruising, and a petechial rash, it's important to contact your doctor right away. This is especially important if the swelling occurred suddenly, is painful, or if you experience any shortness of breath or dizziness along with the leg swelling. Many MyLupusTeam members have reported similar experiences with unexplained bruising and swelling. While normal labs are reassuring, any new symptoms should be evaluated by your healthcare provider to determine if your treatment plan needs adjustment or if additional monitoring is needed.

March 18, 2025

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