Fatigue is one of the most common and troubling symptoms of lupus (SLE), affecting 67-90% of people with the condition. However, lupus fatigue is specifically caused by the disease activity and inflammation in the body, rather than being the same as CFS/ME.
Lupus-related fatigue tends to worsen during flares and can persist Show Full Answer
Fatigue is one of the most common and troubling symptoms of lupus (SLE), affecting 67-90% of people with the condition. However, lupus fatigue is specifically caused by the disease activity and inflammation in the body, rather than being the same as CFS/ME.
Lupus-related fatigue tends to worsen during flares and can persist regardless of how much rest you get. It affects people physically, cognitively, and emotionally. The main causes of fatigue in lupus include:
• Active disease inflammation
• Pain and joint issues
• Poor sleep quality
• Vitamin D deficiency
• Brain fog/cognitive dysfunction
• Depression and anxiety
• Medications used to treat lupus
• Low physical activity levels
Working with your healthcare provider is important to identify the specific causes of your fatigue and develop an appropriate management plan.
September 20, 2025
Join
Your Privacy Choices
