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Real members of MyLupusTeam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.
A MyLupusTeam Member asked a question 💭

If lupus blood tests are negative

September 30, 2025
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A MyLupusTeam Member

Hello, hope you are well. I consider the fact that my dermatologist decided to do a biopsy and wonder the fact that all my blood tests are good, except the disagreement on the positive RNP with my rheumatologist, how long it would have taken for a diagnosis. When my arm swelled up and my skin came off with the band aid gauze, they didn't seem too worried, like rush in and let's get you a steroid shot. As you know it gets frustrating. Thank you and take care.

October 2, 2025
A MyLupusTeam Member

Treatment is based on what's going on clinically and not just on lab results.

October 2, 2025
A MyLupusTeam Member

Yes, it does get frustrating at times. Hang in there!

October 4, 2025
MyLupusTeam

Even with negative blood test results, you may still develop lupus. While a positive AVISE test suggests a higher likelihood of being correctly diagnosed within two years, it's not yet proven to track disease flares or predict every case.

The key is working closely with your healthcare team to monitor symptoms and adjust Show Full Answer

Even with negative blood test results, you may still develop lupus. While a positive AVISE test suggests a higher likelihood of being correctly diagnosed within two years, it's not yet proven to track disease flares or predict every case.

The key is working closely with your healthcare team to monitor symptoms and adjust treatment as needed, regardless of test results. Your doctor may order additional tests to better understand what's causing your symptoms. If your ANA test is negative but other signs point to lupus, your doctor may recommend additional testing including:

• Complete blood count (CBC)
• Complete metabolic panel (CMP)
• Complement level tests
• Erythrocyte sedimentation rate (ESR)
• C-reactive protein (CRP)
• Urinalysis
• Additional autoantibody testing

These tests help create a complete picture of your condition and guide treatment decisions.

September 30, 2025

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