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A MyLupusTeam Member asked a question 💭
Bridgeport, CT
October 14, 2025
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MCTD (Mixed Connective Tissue Disease) is an overlap syndrome that occurs when someone experiences symptoms of multiple rheumatic diseases simultaneously. If you have MCTD, you may experience symptoms of lupus along with other conditions.

Common symptoms of MCTD include
• Raynaud's phenomenon (fingers/toes turning blue or Show Full Answer

MCTD (Mixed Connective Tissue Disease) is an overlap syndrome that occurs when someone experiences symptoms of multiple rheumatic diseases simultaneously. If you have MCTD, you may experience symptoms of lupus along with other conditions.

Common symptoms of MCTD include:
• Raynaud's phenomenon (fingers/toes turning blue or white when cold)
• Trouble swallowing
• Joint inflammation, pain, and swelling
• Hair loss
• Skin rashes after sun exposure
• Hand swelling A key indicator for MCTD is having a positive RNP antibody test. The test is highly sensitive - 95-100% of people with MCTD will test positive for RNP antibodies. However, your doctor will need to evaluate your specific symptoms and run additional tests to confirm a diagnosis, as RNP antibodies can sometimes appear in lupus as well.

October 14, 2025

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