How can you tell if you're in a flare when you have constant pain, and which condition is causing it with Mixed Connective Tissue Disease (MCTD)?
With MCTD, you have symptoms from multiple conditions at once—lupus, rheumatoid arthritis, myositis, and scleroderma—which makes it tricky to pinpoint what's happening. The Show Full Answer
How can you tell if you're in a flare when you have constant pain, and which condition is causing it with Mixed Connective Tissue Disease (MCTD)?
With MCTD, you have symptoms from multiple conditions at once—lupus, rheumatoid arthritis, myositis, and scleroderma—which makes it tricky to pinpoint what's happening. The overlapping nature means your baseline pain might already be higher than someone with lupus alone.
A flare typically means a noticeable increase in your usual symptoms. Even if you're always in pain, watch for:
- Pain that becomes more intense or spreads to new areas
- New or worsening rashes
- Increased fatigue that doesn't improve with rest
- Fever, headaches, or dizziness
- Mouth or nose sores
One MyLupusTeam member with MCTD shared that their doctor diagnosed them with "MCTD leaning toward lupus and rheumatoid arthritis" based on which symptoms were most prominent.
If you're having trouble distinguishing between your baseline and a flare, talk with your rheumatologist. They can help determine if your symptoms indicate that your MCTD isn't well controlled and whether your treatment plan needs adjustment. Sometimes blood work or imaging can provide objective measures of increased disease activity beyond what you're feeling.
November 8, 2025