Connect with others who understand.

  •   Learn from expert-reviewed resources
  •   Real advice from people who’ve been there
  •   People who understand what you’re going through
Sign Up Log In
All Resources Treatments A-Z Personal Assistant Help Center Crisis
Powered By
Real members of MyLupusTeam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.

Greetings Lupies, does anyone know if folic acid taken with methotrexate cause itching? Scalp, eyes, ears,skin all over?

A MyLupusTeam Member asked a question 💭
Bakersfield, CA
November 11, 2025
 · 
Reactions
A MyLupusTeam Member

Im having annoyng bad itching in my eyes, ears, & scalp & skin its really annoying & im not on methotrexate, they put me & itabout a year ago, i lost 5 pounds the 1st month & another 5 the second month i was on it. she took me off after loosing 10 lbs in 2 months But i cant figure out why i itch so bad, i bought visine for itchy eye & that made my eyes itch even more, i had to put my eye drops for dry eyes in , thank goodness that calmed the itching down, before il itched so bad i dugged my eye out. Does
Mycophenolate cause itching ? Im trying to figure out what might be causing it?

November 12, 2025
A MyLupusTeam Member

Ok thank ill make an appt with my primary Doctor

November 13, 2025
A MyLupusTeam Member

@TeresaAimer2--Please see your doctor to have your itching evaluated, Teresa. There are many possible causes, including allergic reactions, lupus, and metabolic problems.

November 13, 2025
A MyLupusTeam Member

I agree with AI--folic acid (a vitamin) shouldn't cause itching, but MTX can. I hope you get relief soon and check in with your doctor!

November 12, 2025
MyLupusTeam

Does folic acid taken with methotrexate cause itching?

Folic acid itself typically doesn't cause itching. In fact, it's commonly recommended alongside methotrexate to help prevent certain side effects. However, methotrexate alone can cause skin problems, including itching and rashes.

Methotrexate side effects that might Show Full Answer

Does folic acid taken with methotrexate cause itching?

Folic acid itself typically doesn't cause itching. In fact, it's commonly recommended alongside methotrexate to help prevent certain side effects. However, methotrexate alone can cause skin problems, including itching and rashes.

Methotrexate side effects that might explain your symptoms include:

* Skin problems like rashes and itching
* Sensitivity to sunlight
* General skin irritation

Itching all over your scalp, eyes, ears, and skin could be a reaction to methotrexate rather than the folic acid supplement. It's also possible you're experiencing an allergic reaction or another issue unrelated to your medications.

Since you're experiencing widespread itching, it's important to contact your healthcare provider. They can determine whether this is a medication side effect, an allergic reaction, or something else that needs attention. Don't stop taking your medications without talking to your doctor first.

November 11, 2025

Related Questions

View All

skin,burning,more hair lost, itching, more, soars in my mouth

A MyLupusTeam Member asked a question 💭
Minneapolis, MN
December 6, 2015

Lupus Earache and Itchy Ears: Causes and Relief
Can Hydroxychloroquine Cause Acid Reflux?
What Organs Does SLE Affect? Eyes, Skin, Joints, Kidneys, and More