Connect with others who understand.

  •   Learn from expert-reviewed resources
  •   Real advice from people who’ve been there
  •   People who understand what you’re going through
Sign Up Log In
All Resources Treatments A-Z Personal Assistant Help Center Crisis
Powered By
Real members of MyLupusTeam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.

Benlysta side effects

A MyLupusTeam Member asked a question 💭
Washington, DC
December 21, 2025
 · 
Reactions
A MyLupusTeam Member

Benlysta can increase our susceptibility to infections, like other immunosuppressants, Ashanti. Many on MLT take it and seem to tolerate it well, though. I haven't taken it but am considering it.

December 21, 2025 (edited)
MyLupusTeam

What are the side effects of Benlysta?

Benlysta (belimumab) can cause various side effects, and it's important to be aware of them while on this treatment. The medication has a similar safety profile whether taken as an infusion or injection.

Common side effects include
- Fatigue
- Rash (especially if you have Show Full Answer

What are the side effects of Benlysta?

Benlysta (belimumab) can cause various side effects, and it's important to be aware of them while on this treatment. The medication has a similar safety profile whether taken as an infusion or injection.

Common side effects include:
- Fatigue
- Rash (especially if you have photosensitivity)
- Joint pain
- Nausea
- Diarrhea
- Fever
- Headache

Serious side effects to watch for:
- Allergic reactions (particularly with infusions, which is why they're given in a medical setting with monitoring)
- Injection site reactions (if using the subcutaneous form)
- Infusion reactions
- Infections (since belimumab affects your immune system)

If you experience any concerning symptoms while taking Benlysta, reach out to your doctor right away. They can help you manage side effects and determine if any adjustments to your treatment are needed.

It's also worth noting that if you need to stop Benlysta, withdrawal symptoms can occur, including increased fatigue, rash, joint pain, and sometimes memory issues or confusion. Never discontinue this medication without talking to your healthcare provider first, as they can help you taper off safely to minimize flare risk.

December 21, 2025
A MyLupusTeam Member

Benlysta has been a blessing to me. My kidney function improved a bit and I am off prednisone. As @A MyLupusTeam Member said, it makes us more susceptible to infection. I get all of the vaccines suggested by my doctors and frequently wash my hands. If someone is ill in your home, I suggest wiping or spraying all door handles with disinfectant.

December 22, 2025
A MyLupusTeam Member

Hi Tal, welcome. I’ve heard of Benlysta. I hope you can get some relief. I too have gotten the following vaccines: flu, COVID and RSV.
Deb

December 21, 2025

Related Questions

View All

Anyone on Benlysta, what side effects are you having?

A MyLupusTeam Member asked a question 💭
Elkins, AR
April 21, 2015

Side effects of cellcept

A MyLupusTeam Member asked a question 💭
Yazoo City, MS
May 21

Stopping Belimumab: 4 Withdrawal Effects To Look For
Brain Fog and Hydroxychloroquine: Is It a Side Effect?
Are Vivid Dreams a Side Effect of Hydroxychloroquine?