MyLupusTeam

How can blood work show negative for scleroderma but positive for CREST?

CREST is actually a form of limited scleroderma, not a separate condition. The acronym stands for Calcinosis, Raynaud's phenomenon, Esophageal dysmotility, Sclerodactyly, and Telangiectasia.

When blood work shows positive for CREST, it typically means Show Full Answer

How can blood work show negative for scleroderma but positive for CREST?

CREST is actually a form of limited scleroderma, not a separate condition. The acronym stands for Calcinosis, Raynaud's phenomenon, Esophageal dysmotility, Sclerodactyly, and Telangiectasia.

When blood work shows positive for CREST, it typically means specific antibodies associated with limited scleroderma were detected. Your rheumatologist's diagnosis of scleroderma aligns with this finding, as CREST is a subtype of the disease.

The confusion might stem from how test results are reported. You may have tested negative for certain scleroderma-specific antibodies but positive for others that indicate the limited form (CREST).

It's important to discuss these results with your rheumatologist to understand:
* Which specific antibodies were found
* What type of scleroderma you have (limited vs. diffuse)
* How this affects your treatment plan
* What symptoms to monitor

Since you're part of MyLupusTeam, it's worth noting that some people can have overlapping features of lupus and scleroderma, sometimes called mixed connective tissue disease. Your doctor can help clarify your specific diagnosis and create an appropriate treatment approach.

 AI-generated responses are not a substitute for medical advice. These services are not intended to diagnose, treat, or cure any condition or disease. Always ask your doctor about specific health concerns.

Is There a Link Between Dupuytren’s Contracture and Lupus?

Lupus Symptoms With a Negative ANA Test: Understanding Your Test Results