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Dx with SCLE May 25’,
dx UCLE Sept 2025
Dx coeliac 2014
Dx microscopic colitis 2016

February 7
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A MyLupusTeam Member

HCQ can take up to six months to work, Rachel. It's unlikely that the steroid cream is causing the rash to spread, and it is more likely that your treatment is still inadequate. Hopefully, over the next couple of months, you'll have better control from the HCQ, but if not, I would talk to your doctor.

February 8
MyLupusTeam

Why does my SCLE rash return and spread after topical steroid treatment while on hydroxychloroquine?

It's concerning that your rash is returning and spreading despite treatment. There are a few possibilities to consider:

Hydroxychloroquine typically takes time to reach full effectiveness - you've been on it for 4 months Show Full Answer

Why does my SCLE rash return and spread after topical steroid treatment while on hydroxychloroquine?

It's concerning that your rash is returning and spreading despite treatment. There are a few possibilities to consider:

Hydroxychloroquine typically takes time to reach full effectiveness - you've been on it for 4 months, which is still within the adjustment period. Some people need dose adjustments or additional time for the medication to fully control their symptoms.

Topical steroids are usually used for 3-7 days to treat lupus-related rashes. If your rash returns after stopping the cream, it may indicate that the underlying inflammation isn't fully controlled yet by your current treatment plan.

There's also a possibility of an allergic reaction to hydroxychloroquine itself, though this is less common. Signs to watch for include:
* Rashes that are scaly or involve blistering/peeling
* Severe itching
* Hives or welts
* Swelling

It's important to contact your doctor right away about this worsening rash. They may need to adjust your hydroxychloroquine dose, prescribe a different topical treatment, or add another medication to better control your cutaneous lupus. Don't stop your medications without medical guidance, as this can increase flare risk.

February 7

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