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I was diagnosed with SLE. I got thrown off track on diagnosis for awhile because I scored 100 high specificity for anti CN1A which indicates IBM. After neurology cleared me they officially diagnosed with SLE. Shortly after I got APS as well. Was wondering if anyone else has seen this pop up in thier bloodwork. Apparently SLE and Sjogrens tend to pop positive for it as well, but usually they have a lower specificity then I have.

March 24
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Has anyone else tested positive for anti-CN1A antibodies with lupus?

It's understandable that your diagnostic journey has been confusing with such high anti-CN1A specificity. While the search results don't specifically mention anti-CN1A antibodies, they do confirm that having multiple autoimmune conditions alongside lupus is Show Full Answer

Has anyone else tested positive for anti-CN1A antibodies with lupus?

It's understandable that your diagnostic journey has been confusing with such high anti-CN1A specificity. While the search results don't specifically mention anti-CN1A antibodies, they do confirm that having multiple autoimmune conditions alongside lupus is quite common.

Many MyLupusTeam members share similar experiences with overlapping autoimmune conditions. One member mentioned having "eight other patterns from the autoimmune spectrum" when diagnosed with lupus. Another shared having both lupus and Sjögren's.

Your experience with developing APS (antiphospholipid syndrome) after your SLE diagnosis also aligns with what many people experience. It's not unusual for lupus to occur alongside other autoimmune conditions, which is sometimes called polyautoimmunity.

The fact that you tested positive for various autoantibodies makes sense because lupus involves your immune system producing multiple types of autoantibodies. These can create mixed patterns in test results, especially when multiple conditions overlap.

If you have questions about your specific antibody profile and what it means for your health management, your rheumatology team would be the best resource for interpreting these results in the context of your overall symptoms and health history.

March 24

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