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A MyLupusTeam Member asked a question πŸ’­
Watertown, WI

I know 90% of people with lupus has low wbc counts, but in my case, it has always been very high, along with high platelets, yet low to normal rbc. And then there's my spleen that used to work, but somehow died in 2012. Its still inside of me, its just dead.
Anyways, im just wondering why my symptoms are different from everyone else and is it possibly because of the above abnormalities?

May 2
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A MyLupusTeam Member

Karleen, I researched this, as I had not heard of asplenia in lupus patients. A 20-year-old study found that 3-7 % of lupus patients have this condition, and it may be due to vasculitis or antiphospholipid antibodies. I'm sure you know your asplenia makes you even more prone to infections, and I hope your doctor is giving you all the appropriate vaccines, including the meningococcal and Haemophilus vaccines.

May 3
MyLupusTeam

That's a really unique situation, and it makes complete sense to wonder why your blood counts look so different from what's typically described with lupus.

You're right that low white blood cell counts (leukopenia) are very common in lupus, affecting around 50–60% of people with SLE. However, lupus can affect blood counts in Show Full Answer

That's a really unique situation, and it makes complete sense to wonder why your blood counts look so different from what's typically described with lupus.

You're right that low white blood cell counts (leukopenia) are very common in lupus, affecting around 50–60% of people with SLE. However, lupus can affect blood counts in many different directions depending on the individual. A non-functioning spleen (asplenia) is actually a known factor that can cause elevated WBC and platelet counts. The spleen normally helps filter and regulate blood cells, so when it stops working, those counts can rise rather than fall β€” which could explain why your pattern looks so different from others with lupus.

Your combination of:
- High WBC
- High platelets
- Low to normal RBC
- A non-functioning spleen

...suggests your body is responding in its own unique way, possibly shaped significantly by the asplenia. A hematologist (blood specialist) would be the best person to help connect these dots. They can explain how your specific blood abnormalities interact with your lupus and what monitoring or treatment adjustments might be needed for your situation.

Everyone's lupus journey really is different β€” your body is just writing its own chapter! πŸ“–

May 2

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