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Real members of MyLupusTeam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.
A MyLupusTeam Member asked a question 💭
Maryland Line, MD
June 22
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MyLupusTeam

Great question! Several medications commonly used to manage lupus can cause itching, either as a side effect or through drug interactions. Here's a quick rundown:

Hydroxychloroquine (Plaquenil) is one of the most common culprits. It can cause itching and rashes, sometimes even after years of use. One MyLupusTeam member Show Full Answer

Great question! Several medications commonly used to manage lupus can cause itching, either as a side effect or through drug interactions. Here's a quick rundown:

Hydroxychloroquine (Plaquenil) is one of the most common culprits. It can cause itching and rashes, sometimes even after years of use. One MyLupusTeam member shared that after 18 years on Plaquenil, they suddenly experienced unexplained welts and itching all over their body.

Other lupus medications that may contribute to skin reactions and itching include:

- Corticosteroids (like prednisone)
- Immunosuppressants
- Warfarin (used for blood clot prevention in lupus)

Drug interactions that may worsen skin reactions include:

- Antacids containing calcium, magnesium, or aluminum interacting with certain antibiotics
- Multiple antihistamines taken on the same day, which can cause an overdose effect If itching starts after beginning a new medication, it's worth flagging to a rheumatologist right away. They can help determine whether the medication is the cause — and in many cases, itching from a drug reaction clears up once the medication is stopped or adjusted. Never stop taking any lupus medication without speaking to a doctor first.

June 22

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