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Real members of MyLupusTeam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.
August 3
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MyLupusTeam

Skin pigmentation changes can be an unwelcome surprise when taking hydroxychloroquine (Plaquenil). While the search results don't go into specific detail about managing pigmentation, skin reactions from hydroxychloroquine are a known side effect worth discussing with a doctor.

Here are some general steps to consider:

- Talk Show Full Answer

Skin pigmentation changes can be an unwelcome surprise when taking hydroxychloroquine (Plaquenil). While the search results don't go into specific detail about managing pigmentation, skin reactions from hydroxychloroquine are a known side effect worth discussing with a doctor.

Here are some general steps to consider:

- Talk to your rheumatologist — they can assess whether the pigmentation is a side effect or an allergic reaction, and advise on next steps
- Don't stop the medication on your own — your doctor may adjust your dosage or suggest alternatives
- See a dermatologist — they can recommend treatments to manage pigmentation changes specifically
- Monitor for worsening symptoms — if the skin changes are accompanied by itching, hives, swelling, or rash, contact your doctor right away as these could signal an allergic reaction It's also worth noting that hydroxychloroquine stays in your system for about three months, so some skin changes may persist even after stopping the medication. Always loop in your healthcare team before making any changes to your treatment plan.

August 3

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