Azathioprine (brand names Azasan or Imuran) is an immunosuppressant medication that works by interfering with DNA creation, which slows down the immune system. In lupus, the immune system mistakenly attacks healthy tissues — azathioprine helps put the brakes on that process. It's typically recommended when other lupus Show Full Answer
Azathioprine (brand names Azasan or Imuran) is an immunosuppressant medication that works by interfering with DNA creation, which slows down the immune system. In lupus, the immune system mistakenly attacks healthy tissues — azathioprine helps put the brakes on that process. It's typically recommended when other lupus treatments haven't worked well enough. Doctors may specifically prescribe it when there are concerns about:
- Kidney problems
- Potential damage to the brain, heart, or lungs
- Controlling lupus flare-ups more broadly Like most medications, azathioprine does come with some things to watch for. Common side effects can include nausea, diarrhea, and vomiting. Some people also notice weight changes while taking it — often losing weight that was previously gained from steroid treatment.
A MyLupusTeam member shared: *"I was on Imuran since August and have lost over 80 pounds. I had a great deal of extra weight from prednisone."* It's always worth having an open conversation with your doctor or rheumatologist about whether azathioprine is the right fit for your specific situation, especially if digestive side effects are affecting your daily life.
August 23
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