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6 Ways To Soothe Lupus Mouth Sores

Written by Vera Sizensky
Posted on September 2, 2026

 

Systemic lupus erythematosus (SLE) is the most common form of lupus. About 8 percent to 45 percent of people with SLE get sores in the mouth or nose. These sores often appear on the lower lip, the lining of the cheeks, and the roof of your mouth.

While some cause no discomfort, others can make eating and talking painful. Here's what may help.

When To Get Medical Help

Before trying these tips, check for warning signs. Mouth sores that occur along with severely painful ulcers on the gums or tongue or crusting on the lips, fever, or swollen glands can signal a serious drug reaction. If you notice these symptoms, contact a doctor right away or go to the emergency room.

Tip #1

Ask About a Topical Steroid

Mouth sores may improve with topical steroids, which are applied directly to the sore, or intralesional steroids, which are injected into it. If… Read more

Mouth sores may improve with topical steroids, which are applied directly to the sore, or intralesional steroids, which are injected into it. If they don't improve, an oral antimalarial medication may be needed. Ask your doctor whether one of these treatments may be appropriate for you.

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Tip #2

Skip the Foods That Sting

Spicy, acidic, or crunchy foods can make an open sore worse. Try avoiding them while a sore is active and adding them back once it heals. Cool… Read more

Spicy, acidic, or crunchy foods can make an open sore worse. Try avoiding them while a sore is active and adding them back once it heals. Cool, soft, bland foods may be more comfortable to eat.

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Tip #3

Switch to a Soft-Bristled Toothbrush

Firm bristles can make toothbrushing more irritating when you have mouth sores. Try using a soft-bristled toothbrush and a gentle, nonabrasive… Read more

Firm bristles can make toothbrushing more irritating when you have mouth sores. Try using a soft-bristled toothbrush and a gentle, nonabrasive fluoride toothpaste. On days when brushing feels too uncomfortable, rinse your mouth with plain water after eating.

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Tip #4

Review Your Other Medications

Some medications can make dry mouth worse. For example, people with a related condition called Sjögren's disease may need to avoid medications… Read more

Some medications can make dry mouth worse. For example, people with a related condition called Sjögren's disease may need to avoid medications that can make dry mouth worse. These can include decongestants, antihistamines, and antidepressants.

Never stop taking a prescription on your own. Talk with the doctor who prescribed it if you're concerned about dry mouth.

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Tip #5

Have Your Lupus Medications Reviewed, Too

As many as 4 in 10 people with lupus develop mouth sores that aren't associated with active disease. In some cases, medications may be… Read more

As many as 4 in 10 people with lupus develop mouth sores that aren't associated with active disease. In some cases, medications may be responsible.

Every major category of lupus medication can affect the mouth, including:

  • Nonsteroidal anti-inflammatory drugs (NSAIDs)
  • COX-2 inhibitors, a type of anti-inflammatory medication
  • Antimalarials
  • Corticosteroids (steroids)
  • Immunosuppressants, such as methotrexate
  • Rituximab

New mouth sores don't necessarily mean you're having a lupus flare. Ask your healthcare provider whether one of your medications could be contributing.

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Tip #6

Ask for a Soft Tissue Exam at Every Dental Cleaning

Painless sores are easy to miss, which is why a regular soft tissue exam, during which a dentist carefully checks the inside of your mouth, can… Read more

Painless sores are easy to miss, which is why a regular soft tissue exam, during which a dentist carefully checks the inside of your mouth, can be helpful. It takes only a few minutes, and you can ask for it as part of your routine cleaning.

People with lupus should see a dentist at least twice a year, or more often if they have ongoing oral health problems. Tell your dentist you have lupus and ask how familiar they are with caring for people with the condition.

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Now it's your turn

What Has Helped Your Mouth Sores?

What did we miss? We'd love to hear what helps you cope with mouth sores when you have lupus. Share your best tips below.

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