A positive DNA AB (DS) Crithidia test means you have anti-double-stranded DNA antibodies in your blood. This is a significant finding for lupus.
This test is more specific to lupus than the general ANA test. When it's positive, it gives doctors a stronger indication that you may have lupus. About 30 percent of people with Show Full Answer
A positive DNA AB (DS) Crithidia test means you have anti-double-stranded DNA antibodies in your blood. This is a significant finding for lupus.
This test is more specific to lupus than the general ANA test. When it's positive, it gives doctors a stronger indication that you may have lupus. About 30 percent of people with lupus have these antibodies, while fewer than 1 percent of healthy people do.
High levels of anti-dsDNA antibodies are especially important because they often show up during lupus flares, particularly when kidney inflammation (lupus nephritis) is present. This makes the test useful not just for diagnosis, but also for monitoring disease activity.
However, a negative result doesn't rule out lupus - you can still have lupus without these specific antibodies. Your doctor will interpret this result alongside your symptoms and other test results to get the complete picture of your health.
It's best to discuss your specific test results with your rheumatologist, who can explain what they mean for your individual situation and treatment plan.
October 26, 2025
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