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Hopefully you can open this link. Scientists have figured out that mononucleosis has a link to lupus. I had mono in my early 20’s. Would be interesting to know how many of you had a case of mono you were aware of.

Scientists Trace Lupus to One of The World's Most Common Viruses
Scientists Trace Lupus to One of The World's Most Common Viruses
November 16, 2025
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A MyLupusTeam Member

I have never had mononucleosis and have never been exposed to the Epstein-Bar virus... I think researchers will never really know the true cause of lupus and other autoimmune diseases. The Stanford study resulted in a hypothesis... A hypothesis is not a theory and therefore cannot be quantified as absolute proof of cause... In the case of lupus there just isn't enough concrete evidence to prove one way or another that mono and or the Epstein-Bar virus causes or triggers the onset of lupus.

November 18, 2025 (edited)
MyLupusTeam

Are you wondering if having mono in your early 20s could be connected to developing lupus?

Research has indeed found an association between Epstein-Barr virus (EBV) infections, which cause mononucleosis, and an increased risk of developing lupus. Studies suggest that EBV may trigger the production of autoantibodies, leading Show Full Answer

Are you wondering if having mono in your early 20s could be connected to developing lupus?

Research has indeed found an association between Epstein-Barr virus (EBV) infections, which cause mononucleosis, and an increased risk of developing lupus. Studies suggest that EBV may trigger the production of autoantibodies, leading to inflammation in people who are susceptible.

One study found that more than two-thirds of people with systemic lupus erythematosus also had EBV. This doesn't mean everyone who had mono will develop lupus, but it does appear to be one of several environmental factors that may contribute to the disease in some people.

It's worth noting that lupus is thought to develop from a combination of factors including:
- Genetics
- Hormones
- Environmental triggers (like viral infections)
- Other immune system influences

Having had mono is just one piece of the puzzle, and many people with lupus may not recall having it, while many who had mono never develop lupus.

November 16, 2025
A MyLupusTeam Member

I had mono in my 20s.

January 8
A MyLupusTeam Member

As far as I know I have never had mono. I had the Hong Kong flue when I was in grade 7. Have a great day.💐

November 21, 2025
A MyLupusTeam Member

It was about a month after a severe case of EBV that I developed pneumonia and a horrible and chronic GI condition. Avoiding allium in my diet and general self-care are my only weapons against this (and avoiding anything that excites the autoimmune system). I have no diagnosis of SLE despite having nearly all the symptoms and no other causes named: my symptoms are dismissed as IBD since my ana tests don't have the markers required for an actual treatment plan. And yet fibromyalgia was diagnosed in my 20s with only symptomatology as my joint pain, headaches, and cfs. My time and money are better spent doing my own self-care, but I worry that as I age, if something became acute, the lack of diagnostic labels and tools will cause me to suffer with my health and finances. Sigh….

November 17, 2025

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