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A MyLupusTeam Member asked a question 💭

Hi all, just wondering how one goes about getting a lupus nepheritis diagnosis? I’ve been struggling with back to back kidney infections and stones that seem directly tied to when I am in a lupus flare. Any insights would be appreciated.

November 26, 2025
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MyLupusTeam

How is lupus nephritis diagnosed?

If you're experiencing kidney issues tied to your lupus flares, it's important to talk with your doctor about testing for lupus nephritis. The diagnosis typically involves several tests:

Urine tests can detect
- Protein in your urine (proteinuria), which makes urine appear foamy
- Blood in Show Full Answer

How is lupus nephritis diagnosed?

If you're experiencing kidney issues tied to your lupus flares, it's important to talk with your doctor about testing for lupus nephritis. The diagnosis typically involves several tests:

Urine tests can detect:
- Protein in your urine (proteinuria), which makes urine appear foamy
- Blood in your urine (hematuria)

Blood tests check for:
- High levels of creatinine, a waste product that healthy kidneys normally filter out
- Overall kidney function

Kidney biopsy may be performed:
- A small tissue sample is taken from your kidney
- Examined under a microscope to confirm inflammation and assess damage severity
- Usually done under light sedation in a hospital or outpatient center

Your doctor should also monitor your blood pressure, since kidney damage from lupus nephritis can cause hypertension. Since you're experiencing recurrent kidney infections and stones during flares, these could be signs of lupus nephritis. Other symptoms to watch for include swelling in your legs, feet, or face, frequent urination (especially at night), and weight gain.

It's worth noting that up to 50 percent of adults with lupus develop lupus nephritis, often within five years of lupus symptoms starting. Getting treatment early is very important to protect kidney function, so reach out to your doctor soon about these symptoms.

November 26, 2025

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