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A MyLupusTeam Member asked a question 💭
Bairnsdale, Victoria, Australia

I have seen a Neurologist & had a MRI on my Lumbar Spine which confirms that I have Degenerative Disc Disease, 2 slipped vertebrae & nerve compression. (very painful)

December 27, 2025
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MyLupusTeam

Can lupus damage your spine and cause degenerative disc disease and slipped vertebrae?

Yes, lupus can affect your spine and contribute to these conditions. When lupus affects the spine, the immune response attacks normal proteins, leading to joint and nerve destruction, bone loss, inflammation, and swelling. As damage Show Full Answer

Can lupus damage your spine and cause degenerative disc disease and slipped vertebrae?

Yes, lupus can affect your spine and contribute to these conditions. When lupus affects the spine, the immune response attacks normal proteins, leading to joint and nerve destruction, bone loss, inflammation, and swelling. As damage occurs, your spinal discs become less able to absorb shock, which can lead to the pain associated with degenerative disc disease.

Lupus has been linked to several spinal complications, including:

- Degenerative disc disease (DDD)
- Spondylolisthesis (when a vertebra moves out of its normal alignment - this is what's commonly called a "slipped vertebra")
- Spinal stenosis (narrowing of the space around the spinal cord)
- Herniated discs
- Bone loss and increased fracture risk

The nerve compression you're experiencing is particularly common with these conditions. When spinal discs wear down, the vertebrae can rub together and put pressure on nearby nerves, causing pain that may radiate down your legs and buttocks.

It's worth noting that lupus medications, particularly corticosteroids like prednisone, can also affect your spine by increasing the risk of osteoporosis, which weakens bones and can lead to vertebral fractures. If you're taking steroids, talk with your doctor about strategies to keep your bones strong, such as calcium, vitamin D, or hormone supplements.

December 27, 2025

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