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Real members of MyLupusTeam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.

Talk to me about methotrexate. My Dr wanted to add to help with my back pain, but I just don't know how I feel about taking it.

A MyLupusTeam Member asked a question 💭
Bixby, OK
March 24
 · 
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MyLupusTeam

How does methotrexate help with lupus-related pain?

Methotrexate is a disease-modifying antirheumatic drug (DMARD) that works by slowing down your immune system's activity. It helps reduce inflammation, which can relieve joint pain and swelling associated with lupus.

Many MyLupusTeam members have found it helpful
- One Show Full Answer

How does methotrexate help with lupus-related pain?

Methotrexate is a disease-modifying antirheumatic drug (DMARD) that works by slowing down your immune system's activity. It helps reduce inflammation, which can relieve joint pain and swelling associated with lupus.

Many MyLupusTeam members have found it helpful:
- One member shared: "I started taking methotrexate and it has worked for me. Flares are remarkably reduced."
- Another said: "I have been on methotrexate since 2014, and it has helped me a lot. The swelling around the joint areas has gone down."

Most people take it once weekly, either by mouth or injection. Your doctor typically prescribes folic acid supplements alongside it to help prevent certain side effects. What are the potential side effects?

Common side effects include:
- Gastrointestinal issues (nausea, vomiting, upset stomach, diarrhea)
- Mouth sores
- Fatigue and weakness
- Hair loss
- Decreased appetite
- Headache and dizziness

More serious but less common effects can include liver problems, blood cell changes, and lung issues. Side effects are more likely at higher doses, and taking folic acid can reduce gastrointestinal side effects by up to 79 percent.

It's completely understandable to feel hesitant about starting a new medication. Talk with your doctor about your specific concerns, the dose they're recommending, and how they'll monitor you. They can help you weigh the potential benefits for your back pain against the risks.

March 24
A MyLupusTeam Member

Thanks for the input, Brittany! My lower back pain is pretty awful most times, but I still just don't know if I want to add another medication to my routine yet :/

March 25
A MyLupusTeam Member

I avoided it too and then just started taking it two months ago after a terrible flare where I could barely walk. It definitely makes you feel worse before better similar to hydroxychloroquine. My joint pain has cut in half but I still have it not sure if it’s worth it yet.

March 24

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