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Real members of MyLupusTeam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.

Can you tell me the difference between Truxima and Ruxience?

A MyLupusTeam Member asked a question 💭
Palm Bay, FL

My insurance won't cover my Rituxan and wants me to try one of these first. But I've never heard of them before so I'd love advice from my community 💜

April 3
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Reactions
A MyLupusTeam Member

They are essentially the same medication, just under different names, Camille. Alethia is right about a prior authorization, but there's probably no point to it. Good luck!

April 4 (edited)
A MyLupusTeam Member

Thank you so much 😊 I appreciate it @A MyLupusTeam Member 💜

April 3
A MyLupusTeam Member

One is covered (the generic), and the other is what they call non-formulary, meaning it is not covered under the prescription plan you have. The only way it may be potentially covered is if your prescribing doctor submitted a prior authorization with the medical notations stating why it's medically necessary to have that prescription. Hope this helps!

April 3 (edited)
MyLupusTeam

What's the difference between Truxima, Ruxience, and Rituxan?

Great question! Truxima and Ruxience are biosimilar versions of Rituxan (rituximab). Think of them like generic versions of a brand-name drug, but for biologics. They work the same way as Rituxan and are designed to have the same effectiveness and safety profile.

Show Full Answer

What's the difference between Truxima, Ruxience, and Rituxan?

Great question! Truxima and Ruxience are biosimilar versions of Rituxan (rituximab). Think of them like generic versions of a brand-name drug, but for biologics. They work the same way as Rituxan and are designed to have the same effectiveness and safety profile.

Insurance companies often prefer biosimilars because they cost less than the original brand-name medication. The good news is that many people with lupus have successfully switched to biosimilars without noticing any difference in how well their treatment works.

Since Rituxan is sometimes used off-label for lupus when other treatments haven't worked, the same applies to its biosimilars. They're all biologic therapies that block specific inflammatory proteins in your immune system to help reduce lupus-related inflammation.

If you're concerned about switching, talk openly with your rheumatologist. They can help you understand what to expect and monitor how you respond to the biosimilar. Many people find that biosimilars work just as well as the original medication, and switching can help you access the treatment you need while working within your insurance coverage.

Your doctor is your best resource for making this decision based on your specific health history and needs.

April 3

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