I just went thru that,finally took a half dose of Benadryl,that helped a lot with itching and helped me sleep!
April 27
Full body itching with lupus can be really miserable, but there are quite a few options worth exploring beyond hydrocortisone. Here's a breakdown of what may help:
Medications (talk to your doctor first)
- Antihistamines like cetirizine (Zyrtec) or loratadine taken daily can help manage itching and hives
- Prescription Show Full Answer
Full body itching with lupus can be really miserable, but there are quite a few options worth exploring beyond hydrocortisone. Here's a breakdown of what may help:
Medications (talk to your doctor first):
- Antihistamines like cetirizine (Zyrtec) or loratadine taken daily can help manage itching and hives
- Prescription topical steroids like clobetasol propionate cream for targeted relief
- Oral steroids like prednisone during bad flares
- Antimalarial medications like hydroxychloroquine (Plaquenil), which help manage lupus skin symptoms long-term
- Monthly injections of omalizumab (Xolair) — a MyLupusTeam member shared it helped "like a miracle" after years of suffering At-home relief options:
- Apply ice packs directly to itchy areas
- Use compression sleeves or leggings on affected areas
- Try witch hazel on the skin — it won't cure anything but can soothe discomfort
- Rubbing alcohol on a cotton ball followed by a prescription cream has worked for some
- Aloe vera gel, shea butter, or emu oil applied regularly can help soothe irritated skin
Sun protection is key — UV exposure is a major trigger. Use broad-spectrum SPF 60+ sunscreen, wear protective clothing, and swap fluorescent bulbs for LED lighting indoors.
Always check with your doctor before adding new medications or supplements, as interactions with existing lupus treatments are possible.
April 27
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