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Real members of MyLupusTeam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.

Since i devopled a toxicity to plaquenil what's the next best med.

A MyLupusTeam Member asked a question 💭
Oxford, MS
June 8
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Reactions
A MyLupusTeam Member

Machel, what was your dosage per day of Plaquenil? I used to be on 200 mg twice a day, but after a couple of years my Rheumatologist recommended going to once a day due to fear of toxicity. I have been on once-a-day pill for over 20 yrs with no problems, thank the Lord.

June 8
A MyLupusTeam Member

Hi Machel, I am sorry to hear this. Did your rheumatologist suggested Benlizta. I am on it and it’s helping me

June 9
A MyLupusTeam Member

I was on 300 mg 1 x a day for 2 years. i got toxic from it (spot on my Retina) and I talked to my Rheumatologist and we both agreed to just see how I do on Myfortic (cellucept). Myfortic did stop my b/p from bottoming out on me but it does come with side effects. Talk with your Rheumatologist. Praying for you Machel! God bless.

June 8
MyLupusTeam

Developing a toxicity to Plaquenil (hydroxychloroquine) is definitely a challenge, but there are other options that a rheumatologist can explore with you. The right choice really depends on your specific symptoms, how active your lupus is, and your overall health picture.

Here are some commonly used alternatives for managing Show Full Answer

Developing a toxicity to Plaquenil (hydroxychloroquine) is definitely a challenge, but there are other options that a rheumatologist can explore with you. The right choice really depends on your specific symptoms, how active your lupus is, and your overall health picture.

Here are some commonly used alternatives for managing lupus:

- Corticosteroids (like prednisone) – often used to reduce inflammation and control flares
- Immunosuppressants (like methotrexate, azathioprine/Imuran, or mycophenolate/CellCept) – help calm the overactive immune response
- Belimumab (Benlysta) – a biologic medication specifically approved for lupus
- Voclosporin or anifrolumab – newer biologics that may be options depending on your situation

Each of these comes with its own set of potential side effects and risks, so it's really important to have a thorough conversation with your rheumatologist about what makes the most sense for you.

Don't hesitate to advocate for yourself in that appointment — your doctor needs to know how your lupus is currently affecting your daily life to make the best recommendation.

June 8

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