Managing SLE with so many overlapping challenges sounds genuinely exhausting — and that exhaustion is real, not just in your head. Many MyLupusTeam members take hydroxychloroquine (HCQ) and methotrexate together, and some do report hair loss and skin changes as concerns worth discussing with their doctor.
When it comes to Show Full Answer
Managing SLE with so many overlapping challenges sounds genuinely exhausting — and that exhaustion is real, not just in your head. Many MyLupusTeam members take hydroxychloroquine (HCQ) and methotrexate together, and some do report hair loss and skin changes as concerns worth discussing with their doctor.
When it comes to HCQ specifically, most people tolerate it well, but there are some skin-related side effects to be aware of, including:
- Skin rashes or reactions
- Blistering (in rare but serious cases, this can signal Stevens-Johnson syndrome — seek immediate medical attention if blistering is severe)
- Hair loss or changes Blistering in particular is considered a serious side effect that warrants contacting a doctor right away. Hair loss and worsening rashes should also be reported promptly, as they may indicate the medication needs to be adjusted.
With everything going on, it's really important not to stop either medication suddenly without speaking to your rheumatologist first — stopping abruptly can increase the risk of lupus flares.
Your care team can help sort out whether these symptoms are medication-related or lupus activity, and adjust your treatment plan accordingly. You deserve to feel heard and supported through all of this. 💙
July 7
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