Taking prednisone and hydrocortisone together is something to approach with real caution — both are corticosteroids, meaning they work in a very similar way. Combining them could amplify side effects significantly.
Some of the risks of taking two corticosteroids together can include:
- Higher risk of infection due to further Show Full Answer
Taking prednisone and hydrocortisone together is something to approach with real caution — both are corticosteroids, meaning they work in a very similar way. Combining them could amplify side effects significantly.
Some of the risks of taking two corticosteroids together can include:
- Higher risk of infection due to further immune suppression
- Increased blood sugar levels
- Greater chance of bone loss over time
- More fluid retention and higher blood pressure
- Increased adrenal suppression
This is really a conversation to have with your rheumatologist before making any changes. They'll know your full health history and can advise whether there's a safe reason to use both, or whether one should replace the other.
In the meantime, never stop or adjust prednisone suddenly — that can be dangerous on its own.
August 5
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