MyLupusTeam

Yes, Plaquenil (hydroxychloroquine) can cause itching, and for some people it can be quite severe. Itching can happen anywhere on the body and may be a sign of an allergic reaction rather than just a side effect.

A MyLupusTeam member shared that after just four days on Plaquenil, the itching was so unbearable it kept them up Show Full Answer

Yes, Plaquenil (hydroxychloroquine) can cause itching, and for some people it can be quite severe. Itching can happen anywhere on the body and may be a sign of an allergic reaction rather than just a side effect.

A MyLupusTeam member shared that after just four days on Plaquenil, the itching was so unbearable it kept them up all night, leaving bruises from scratching. Another member who had been on it for 18 years suddenly developed unexplained welts and itching that only eased after taking Benadryl. It's worth knowing that itching can also be a lupus symptom itself, so it's not always easy to tell the cause. Signs that itching may be an allergic reaction to Plaquenil include:

- Itching that starts shortly after beginning the medication
- A rash, hives, or swelling alongside the itching
- Scaly, blistering, or peeling skin

If the itching is severe or comes with swelling of the face, lips, tongue, or throat, contact your doctor right away — that can be a sign of a serious allergic reaction. Your doctor can help figure out the cause and whether Plaquenil needs to be stopped.

 AI-generated responses are not a substitute for medical advice. These services are not intended to diagnose, treat, or cure any condition or disease. Always ask your doctor about specific health concerns.

5 Signs of a Hydroxychloroquine Allergic Reaction