How can you tell if you're experiencing a flu or cold versus a lupus flare when symptoms overlap?
It can be tricky since lupus flares and infections share similar symptoms like fever, fatigue, and body aches. Here are some ways to help distinguish between them:
Key differences to watch for
* If your fever doesn't improve Show Full Answer
How can you tell if you're experiencing a flu or cold versus a lupus flare when symptoms overlap?
It can be tricky since lupus flares and infections share similar symptoms like fever, fatigue, and body aches. Here are some ways to help distinguish between them:
Key differences to watch for:
* If your fever doesn't improve after taking acetaminophen or NSAIDs (like ibuprofen), it's more likely an infection. Fevers from lupus flares typically respond to these medications.
* A fever over 101 degrees Fahrenheit that won't go away is more concerning for infection and needs medical attention right away.
* New respiratory symptoms like persistent cough, congestion, or sore throat point more toward a cold or flu.
Why it matters:
Your healthcare provider may order blood tests to check for biological markers that show whether a fever is from infection or lupus disease activity. This is important because treatments differ depending on the cause.
Since lupus itself and immunosuppressive medications can weaken your immune system, you're at higher risk for infections. Always contact your doctor if you have a fever lasting more than a day or two, or any new or worsening symptoms.
November 17, 2025
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