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Real members of MyLupusTeam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.
A MyLupusTeam Member asked a question 💭
January 31
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What side effects have you experienced while taking methotrexate for lupus?

Many MyLupusTeam members take methotrexate and have shared their experiences. Some have found it helpful for managing symptoms, while others have dealt with various side effects.

Common side effects reported include:

* Gastrointestinal issues like Show Full Answer

What side effects have you experienced while taking methotrexate for lupus?

Many MyLupusTeam members take methotrexate and have shared their experiences. Some have found it helpful for managing symptoms, while others have dealt with various side effects.

Common side effects reported include:

* Gastrointestinal issues like nausea, vomiting, heartburn, acid reflux, and stomach pain
* Mouth sores or ulcers and sore gums
* Fatigue and weakness
* Hair loss
* Headaches
* Dizziness
* Decreased appetite
* Diarrhea

Some members have also mentioned experiencing tooth pain or sensitivity, though this isn't officially listed as a side effect. One member shared: "I've been taking methotrexate for a few months now, and my molars have been hurting."

The good news is that many members have found methotrexate effective. One shared: "I have been on methotrexate since 2014, and it has helped me a lot. The swelling around the joint areas has gone down."

Your doctor may prescribe folic acid supplements alongside methotrexate to help prevent some side effects. If you're experiencing troublesome side effects, especially severe stomach issues or black stool, contact your doctor right away as these could indicate more serious complications.

January 31

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