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Real members of MyLupusTeam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.

Has anyone else experienced these strange symptoms?

A MyLupusTeam Member asked a question in Flare-Ups group 💭
Atlanta, GA

I have experienced some strange symptoms that no one can explain. I dont know what triggers it and was wondering if anyone else has experienced it. Let me know!

I have episodes of extreme, intense itching of the palms of my hands and soles of my feet. After which, hives will creep up my arms and legs but the hives dont itch very much unless it gets really bad. I also experience vertigo, nausea, vomiting and diarrhea. It only lasts 1-4 hours. It comes on very quickly and dissipates just as… read more

April 6
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Reactions
A MyLupusTeam Member

I have almost all of what you mentioned. I get hives but mine itch. I’ve had vertigo sometimes and throwing up. I definitely get itching on the soles of my feet. My doctor said these are signs I might be in a flare up. Lupus has some very strange symptoms. I hope you feel better soon.

April 16
A MyLupusTeam Member

My history with this is such bad pressure didn't know if I had to go to the bathroom or throw up unfortunately for over 6 years before being diagnosed

April 10
A MyLupusTeam Member

Yes! This is exactly what I deal with. Not only intense itching in my palms, but around the nails. It’s soooo frustrating. It sounds to me like it could be a flare. What other symptoms do you have? Do the symptoms seem to come and go at various times?

April 10
A MyLupusTeam Member

I also ich from my head to my toes. This last time it lasted 6 months. A few minutes of break here and there during the day. I tried everything. Creams, ointment doctors prescribed. I saw an allergist for 5 years. She gave me injections claim I was allergic to dust and mold.
This last flare up my daughter suggested I tried ALLEGRA.
Believe me it worked!
I take two recommendations is one daily.
Little by little I felt the inches leave my body. Oh I inch,once in awhile, not the while body. A little of OTC cortisone takes care of it.
I wish you all the best.

April 10
MyLupusTeam

What could be causing intense itching on your palms and feet with hives on your arms and legs?

The intense itching on your palms and feet followed by hives sounds challenging, and it's understandable you're looking for answers. Several possibilities related to lupus could explain these symptoms:

Dyshidrotic eczema is a Show Full Answer

What could be causing intense itching on your palms and feet with hives on your arms and legs?

The intense itching on your palms and feet followed by hives sounds challenging, and it's understandable you're looking for answers. Several possibilities related to lupus could explain these symptoms:

Dyshidrotic eczema is a condition that some people with lupus experience. It causes small, itchy blisters on the hands and feet, along with burning, peeling, and rashes. A MyLupusTeam member described similar symptoms: "A bumpy, itchy rash comes and goes on my hands due to stress or extreme fatigue, but it's almost constant on my feet."

This condition can be triggered by:
- Stress
- Extreme fatigue
- Sun exposure
- Contact allergies

Medication reactions are another possibility if you're taking hydroxychloroquine (Plaquenil) or other lupus medications. Itching and hives are common allergic reactions to these drugs. One member shared: "The itch was unbearable, where I was up all night. I have bruises up and down my legs from scratching so hard."

Peripheral neuropathy related to lupus can cause unusual sensations including tingling, burning, or stinging feelings, particularly in the hands and feet. Could this be a lupus flare?

Your husband may be onto something. The quick onset and resolution of your symptoms, along with the combination of skin and digestive issues, could indicate a flare. Lupus flares can present with various symptoms that come on suddenly.

The fact that your episodes last 1-4 hours and include multiple body systems (skin, digestive, balance) suggests your body is reacting to something, whether it's a flare trigger or an allergen.

Next steps to consider:

Keep a detailed symptom diary tracking:
- What you ate or drank before episodes
- Activities or environments you were in
- Stress levels
- Weather or temperature changes
- Any new products (soaps, lotions, detergents)

Since your primary care doctor suspects allergies, you might benefit from seeing an allergist who can perform testing. They can help identify specific triggers that might be causing these acute episodes.

Given that multiple specialists haven't found an explanation, documenting patterns could help identify what's triggering these episodes and whether they're related to lupus activity or something else entirely.

April 6

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