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Real members of MyLupusTeam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.

Is everyone familiar with the side effects of over-the-counter NSAIDS like ibuprofen and naproxen?

A MyLupusTeam Member asked a question 💭
Pittsboro, NC

Please be aware that these drugs aren't necessarily safe, although they're over the counter. They can cause kidney injury, gastritis, ulcers, gastrointestinal bleeding, increased BP, and worsen heart failure, among their many possible side effects. For those on steroids, the ulcer/gastritis and bleeding risk is increased.

PLEASE talk to your doctor before using these meds, given our higher risk for problems!

July 7
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Answer Summary

Members responded to an important reminder about the risks of over-the-counter NSAIDs like ibuprofen and naproxen, with many sharing that... Read more

Members responded to an important reminder about the risks of over-the-counter NSAIDs like ibuprofen and naproxen, with many sharing that their doctors had already advised them to avoid these medications. Several members noted personal reasons for steering clear, including being on blood thinners, having a recent stent, or managing kidney concerns, with many turning to Tylenol or topical options like Voltaren cream instead. A recurring theme was gratitude for the helpful information, and the importance of talking with a doctor before using any pain reliever.

MyLupusTeam

What important things should people with lupus know about over-the-counter NSAIDs like ibuprofen and naproxen?

This is such an important heads-up, and it's exactly the kind of thing that can catch people off guard. "Over the counter" can feel synonymous with "safe," but that's not always the case — especially with lupus.

Here Show Full Answer

What important things should people with lupus know about over-the-counter NSAIDs like ibuprofen and naproxen?

This is such an important heads-up, and it's exactly the kind of thing that can catch people off guard. "Over the counter" can feel synonymous with "safe," but that's not always the case — especially with lupus.

Here are some key risks to be aware of:

- Kidney damage — particularly concerning for those with lupus nephritis
- Stomach ulcers and gastritis
- Gastrointestinal bleeding
- Increased blood pressure
- Swelling and water retention For those also taking corticosteroids like prednisone, the risks are even higher. Studies show the risk of stomach ulcers can be more than four times greater when combining steroids with NSAIDs compared to not taking them at all. Similarly, combining duloxetine (Cymbalta) with naproxen raises the risk of dangerous bleeding events, since duloxetine affects blood clotting. Those at higher risk include older adults, people with kidney or liver involvement, and those on blood thinners.

The bottom line — always check with your rheumatologist or pharmacist before adding any OTC pain reliever to your routine. What's harmless for someone else could be a real problem with lupus in the picture.

July 7
A MyLupusTeam Member

My rhemotoid says it is ok to take Aleve. That's what I take if I really have too.
I will do Tylenol if I need it

July 8
A MyLupusTeam Member

Always aware thank you for the reminder

July 7
A MyLupusTeam Member

Sorry, I said can't cause, I meant can cause. Sorry

July 7
A MyLupusTeam Member

@A MyLupusTeam Member thank you for clarifying the effects of NSAIDs , i was hoping you would be able to clarify it for me, thanks i appreciate it.

July 11

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