Finding a new lump on your body can be worrisome, and it’s important to know whether or not it’s something serious. People living with lupus sometimes develop a type of lump called a ganglion cyst. These fluid-filled lumps are usually harmless and painless and can appear near joints or tendons of the wrists, fingers, or feet. Ganglion cysts are the most common benign (noncancerous) lesions of the hand and wrist.

“Does anyone else suffer from this in the hands or wrists?” one MyLupusTeam member asked. Another replied, “Yes, I had a ganglion cyst on my right wrist. I am told it’s common in lupus.”

In this article, we’ll explain what ganglion cysts are, if they could be related to lupus, and whether they require any treatment.

What Are Ganglion Cysts?

A ganglion cyst is a harmless lump or nodule that typically appears near joints or tendons. Ganglion cysts are often found in the wrists, hands, or fingers, but they can also appear on the ankles and feet.

Ganglion cysts are filled with a thick, jellylike fluid that is very similar to the fluid in your joints. These cysts are often round or oval and can vary in size, ranging from small, like a pea, to larger than an inch in diameter.

Ganglion cysts aren’t cancerous, and they’re usually harmless, but in some cases, they may require treatment.

What Are the Symptoms of Ganglion Cysts?

Ganglion cysts can cause specific symptoms that vary depending on their size and location, and whether they’re close to nerves or blood vessels. While many ganglion cysts don’t cause any problems and can go unnoticed, some people may experience the following symptoms:

• Discomfort or pain — Although most ganglion cysts aren’t painful, they can cause discomfort or joint pain if they exert pressure on nearby nerves or blood vessels. The pain can be described as a dull ache or a sharp, shooting sensation, and it may worsen during specific movements or activities.
• Limited range of motion — In certain cases, ganglion cysts can interfere with how your joint moves, limiting your range of motion. This can impact daily activities.
• Tingling or numbness — When a ganglion cyst puts pressure on a nerve, it can cause tingling or numbness in the affected area. This feeling is often described as a pins-and-needles sensation.
• Changes in skin texture — Ganglion cysts can sometimes cause changes to the skin on top of it. The skin may appear shiny, stretched, or discolored.

It’s important to know that ganglion cysts can sometimes look like other conditions, such as tumors or cysts from different causes. So, if you notice a lump or experience any of the symptoms mentioned above, it’s a good idea to see a rheumatologist or another healthcare professional to get an accurate diagnosis.

Are Ganglion Cysts Related to Lupus?

Ganglion cysts aren’t directly caused by systemic lupus erythematosus (SLE) — the most common type of lupus — but they may be related in other ways. Lupus mainly affects your immune system, causing it to mistakenly attack healthy tissues and organs.

Musculoskeletal symptoms like inflammation and joint pain are commonly associated with SLE. Despite this, lupus does not specifically cause ganglion cysts.

Can You Get Cysts From Lupus?

People with lupus often develop other types of joint-related conditions, such as arthritis, tendonitis, or Sjögren’s disease. And while it’s not a primary symptom, people living with lupus sometimes develop ganglion cysts. However, there is no evidence that lupus causes these cysts.

In one study, researchers evaluated the wrist joints of 26 people with SLE. While inflammation was found in almost half of the wrists, ganglion cysts were found in only 3.8 percent. However, the exact prevalence of such cysts in people with lupus is unknown, and more research is needed.

What Causes Ganglion Cysts?

Doctors aren’t sure what causes ganglion cysts. Researchers believe they develop when synovial fluid leaks out or bulges from nearby joints or tendons.

Ganglion cysts might show up or grow larger due to overuse of a joint or minor injuries to the area. Anyone can develop ganglion cysts, but according to Cleveland Clinic, they’re three times more common in females than in males and tend to appear between the ages of 20 and 50.

Some of the other risk factors for developing ganglion cysts may include a past injury to the joint or an autoimmune disease or inflammatory condition, such as osteoarthritis, rheumatoid arthritis, or gout.

How Are Ganglion Cysts Diagnosed?

By combining the following methods, doctors can typically diagnose a ganglion cyst:

• Physical examination — Your doctor will consider your health history and examine the lump or swelling.
• Transillumination — This technique involves shining a light through the cyst to assess whether it is filled with fluid and may be a ganglion cyst.
• Ultrasound — An ultrasound imaging scan uses sound waves to create real-time images of the cyst and the surrounding tissues. It helps a doctor distinguish ganglion cysts from other types of lumps or tumors.
• MRI scan — Magnetic resonance imaging uses a powerful magnetic field and radio waves to take detailed images. This allows your doctor to see a cyst’s size, shape, and location and how it’s affecting nearby body parts.
• X-ray — Although ganglia aren’t visible on X-rays, your doctor may use this imaging technique to rule out other conditions, such as fractures or arthritis.
• Aspiration — An aspiration procedure involves using a needle to withdraw fluid from the cyst for further testing.

How Are Ganglion Cysts Treated?

About 58 percent of ganglion cysts will go away on their own over time. If your cyst is small, painless, and doesn’t interfere with your ability to carry out daily activities, your doctor might suggest keeping an eye on it without doing anything. However, if your cyst is causing pain or interfering with your daily activities, your doctor may recommend treatment.

There are a few treatment options for ganglion cysts:

• Immobilization — Wearing a brace or splint to keep nearby joints from moving may help relieve symptoms and shrink your cyst.
• Anti-inflammatory medications — Medications like nonsteroidal anti-inflammatory drugs (NSAIDs) may help treat any pain and swelling.
• Aspiration — Your doctor may use a needle and syringe to drain the fluid from the cyst. This procedure can provide temporary relief, but cysts often return after aspiration because their connection to the joint isn’t completely removed.
• Surgical removal — This procedure is usually done in a clinic while you are awake with the affected area numbed. This treatment is usually the most effective, with low rates of recurrence (cysts coming back).
• Steroid injections — Steroids are sometimes used to treat ganglia that are causing pain and discomfort. However, many physicians do not recommend them because research shows they offer no added benefit compared to aspiration and they can cause side effects.
• Physical therapy — After treating your ganglion cyst, you may need physical therapy to help bring your joint back to normal. A physical therapist can suggest ways to avoid overusing your joint so the cyst does not come back.

You may have heard stories of people popping ganglion cysts by hitting them with heavy objects, like a book. Researchers strongly recommend against this approach, as it can lead to infections or other unwanted complications. Popping the cyst intentionally won’t destroy the cyst’s walls, and it is likely to return. It’s important to consult a rheumatology professional to get an accurate diagnosis and the right treatment for a ganglion cyst.

Your Doctor Is Your Best Resource

If you have a ganglion cyst or another lump or swelling, and you’re worried it’s related to lupus, it’s best to talk with your rheumatologist or other healthcare professionals. They are your best resource for figuring out the root cause of your symptoms and developing a treatment plan that won’t interfere with your existing lupus treatments.

Talk With Others Who Understand

On MyLupusTeam — the social network for people with lupus and their loved ones — members come together to ask questions, give advice, and share their stories with others who understand life with lupus.

Have you had a ganglion cyst? What was your experience getting a diagnosis and having it treated? Share your experience in the comments below, or start a conversation by posting on your Activities page.