I have seronegative lupus. No markers at all. Solely clinical symptoms.

Me too! ANA negative etc but low complement levels.

Thanks all for your response. I was wondering why i have been taking plaquenil for over 2 years but not feeling better, though blood test result showing improvement. My GP blames anything he cant answer to lupus while my Rheumatologist only relies on blood test result to treat me. Indeed, I feel better before the lupus treatment.