Connect with others who understand.

  •   Learn from expert-reviewed resources
  •   Real advice from people who’ve been there
  •   People who understand what you’re going through
Sign Up Log In
All Resources Treatments A-Z Personal Assistant Help Center Crisis
Powered By
Real members of MyLupusTeam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.

I was recently diagnosed with Lupus. I just received my AVIS test, and it came back negative for connective tissue disease. Normal?

A MyLupusTeam Member asked a question 💭
Dayton, OH
December 1, 2025
 · 
Reactions
A MyLupusTeam Member

Just regular ANA tests can come up negative if you are receiving treatment and/or your condition is stable.

December 2, 2025 (edited)
A MyLupusTeam Member

Do you mean mixed connective tissue disease? With the blood work, it can look different ways at different times. Are you on medication? You have a diagnosis. As long as you’re getting treatment and it’s controlling your symptoms, I wouldn’t worry about it.

December 1, 2025
A MyLupusTeam Member

It certainly may provide more information, but it still notes an error rate. Like may tests, certain medications and herbals can interfere with accuracy.

December 1, 2025
A MyLupusTeam Member

I havent heard of this test

December 1, 2025
MyLupusTeam

Is it normal to have a negative AVISE test after being diagnosed with lupus?

Yes, it's possible to have a negative AVISE Connective Tissue Disease test even after a lupus diagnosis. This test won't predict every case, and some people with lupus will have negative results.

The AVISE test is often used when symptoms or other Show Full Answer

Is it normal to have a negative AVISE test after being diagnosed with lupus?

Yes, it's possible to have a negative AVISE Connective Tissue Disease test even after a lupus diagnosis. This test won't predict every case, and some people with lupus will have negative results.

The AVISE test is often used when symptoms or other lab results are unclear, or to provide additional information when diagnosis is uncertain. However, it's not required for diagnosis and a negative result doesn't mean your lupus diagnosis is incorrect.

Since you were recently diagnosed with lupus, your doctor likely used other important factors to make that diagnosis, such as:

- Your symptoms and physical examination
- ANA test results
- Other antibody tests (like anti-dsDNA or anti-Sm)
- Blood counts and kidney function tests
- Overall clinical picture

If you have concerns about your test results or diagnosis, it's worth discussing with your rheumatologist. They can explain how all your test results fit together and why they reached your lupus diagnosis despite the negative AVISE result.

December 1, 2025

Related Questions

View All

Avise SLE+Connective tissue 2.0 test

A MyLupusTeam Member asked a question 💭
Wamego, KS
November 11, 2015

Lupus Symptoms With a Negative ANA Test: Understanding Your Test Results
You’ve Just Been Diagnosed With Lupus. Now What?
What I Want Others to Understand About Lupus