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Real members of MyLupusTeam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.
July 25
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A MyLupusTeam Member

I remember my rheumatologist mentioned something about him believing my SLE was caused by a mutation of the cell from the bone marrow, or something like that. It was when I was going through a really bad brain fog and was not retaining much information, but I was told by a non-medical provider that stem cell therapy could possibly help my condition, but of course insurance does not cover that.

July 25
MyLupusTeam

That's a really thoughtful question! It gets at something many people with lupus wonder about. Unfortunately, lupus doesn't yet have a known single "cause" that can be directly targeted — it's believed to result from a combination of genetics, hormones, and environmental triggers like infections or smoking.

Because of this Show Full Answer

That's a really thoughtful question! It gets at something many people with lupus wonder about. Unfortunately, lupus doesn't yet have a known single "cause" that can be directly targeted — it's believed to result from a combination of genetics, hormones, and environmental triggers like infections or smoking.

Because of this, most current treatments focus on calming the immune system's overactivity rather than eliminating a root cause. However, some treatments do go deeper than just managing symptoms:

- Hydroxychloroquine (Plaquenil) — helps "reset" immune system behavior, not just mask symptoms
- Immunosuppressants — work to reduce the immune system's attack on the body
- Biologics like belimumab — target specific immune pathways involved in lupus activity
- CAR T-cell therapy — an emerging experimental treatment that may offer long-term remission by reprogramming immune cells Researchers are actively exploring new therapies through clinical trials, including stem cell transplants and B-cell therapies, which aim to address the underlying immune dysfunction more directly.

So while a true "cure" doesn't exist yet, science is definitely moving in that direction! Always worth discussing the latest options with a rheumatologist.

July 25

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